Dihydrocodeine should be used with caution in the elderly or in patients with:
– history of opioid abuse or dependence
– increased intracranial pressure or head injury
– disorders of the biliary tract
– prostatic hypertrophy
– pancreatitis
– impaired liver function
– severe renal dysfunction
– constipation
– obstructive bowel disorder
– respiratory depression with hypoxia
– chronic obstructive pulmonary disease
– cor pulmonal
– bronchial asthma
– hypothyroidism
Dihydrocodeine should be used with caution in patients taking:
– monoamine oxidase inhibitors
Risk from concomitant use of benzodiazepines (and other CNS depressants):
Concomitant use of benzodiazepines and opioids can lead to sedation, respiratory depression, coma and death.). Patients should be closely monitored for signs and symptoms of respiratory depression and sedation. In this regard, it is strongly recommended to inform patients and their environment so that they are aware of these symptoms.
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