pharmachologic effect
Pharmacological action – antibacterial.
Pharmacodynamics:
Combined bactericidal chemotherapeutic agent.
The drug Bactrim forte contains two active substances that have a synergistic effect, blocking two enzymes that catalyze the successive stages of folinic acid biosynthesis in microorganisms. Due to this mechanism, the bactericidal effect in vitro is achieved at concentrations in which the individual components of the drug have only a bacteriostatic effect. In addition, Bactrim forte is often effective against pathogens that are resistant to one of its components.
The in vitro antibacterial activity of Bactrim forte covers a wide range of gram-positive and gram-negative pathogens, although sensitivity may depend on geographic location.
Usually susceptible pathogens (MIC<80 mg/l for sulfamethoxazole)
Cocci: Branhamella catarrhalis.
Gram-negative microorganisms: Haemophilus influenzae (β-lactamase and β-lactamase-forming strains), Haemophilus parainfluenzae, E. coli, Citrobacter freundii, other Citrobacter species, Klebsiella pneumoniae, Klebsiella oxytoca, other Klebsiella species, Enterobacter cloaceae, Enterobacter aerogenes, Hafnia alvei, Serratia marcescens, Serratis liquefaciens, other Serratia species, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Shigella spp., Yersinia enterocolitica, other Yersinia species, Vibrio cholerae.
Various Gram-negative microorganisms: Edwardsiella tarda, Alcalisenes faecalis, Pseudomonas cepacia, Burkholderia (Pseudomonas) pseudomallei.
Clinical experience shows that Brucella spp., Listeria monocytogenes, Nocar dia asteroides., Pneumocystis carinii, Cyclospora cayetanensis can also be sensitive.
Original
pharmakologische Wirkung
Pharmakologische Wirkung – antibakteriell.
Pharmakodynamik:
Kombiniertes bakterizides Chemotherapeutikum.
Das Medikament Bactrim forte enthдlt zwei Wirkstoffe, die eine synergistische Wirkung haben und zwei Enzyme blockieren, die die aufeinanderfolgenden Phasen der Folinsдure-Biosynthese in Mikroorganismen katalysieren. Aufgrund dieses Mechanismus wird die bakterizide Wirkung in vitro bei Konzentrationen erreicht, bei denen die einzelnen Komponenten des Arzneimittels nur bakteriostatisch wirken. Darьber hinaus ist Bactrim Forte oft wirksam gegen Krankheitserreger, die gegen einen seiner Bestandteile resistent sind.
Die antibakterielle In-vitro-Aktivitдt von Bactrim forte deckt ein breites Spektrum grampositiver und gramnegativer Krankheitserreger ab, obwohl die Empfindlichkeit vom geografischen Standort abhдngen kann.
Ьblicherweise empfindliche Erreger (MHK < 80 mg/l fьr Sulfamethoxazol)
Kokken: Branhamella catarrhalis.
Gram-negative Mikroorganismen: Haemophilus influenzae (Я-Lactamase und Я-Lactamase-bildende Stдmme), Haemophilus parainfluenzae, E. coli, Citrobacter freundii, andere Citrobacter-Arten, Klebsiella pneumoniae, Klebsiella oxytoca, andere Klebsiella-Arten, Enterobacter cloaceae, Enterobacter aerogenes, Hafnia alvei, Serratia marcescens, Serratis liquefaciens, andere Serratia-Arten, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Shigella spp., Yersinia enterocolitica, andere Yersinia-Arten, Vibrio cholerae.
Verschiedene gramnegative Mikroorganismen: Edwardsiella tarda, Alcalisenes faecalis, Pseudomonas cepacia, Burkholderia (Pseudomonas) pseudomallei.
Klinische Erfahrungen zeigen, dass auch Brucella spp., Listeria monocytogenes, Nocar dia asteroides., Pneumocystis carinii, Cyclospora cayetanensis empfindlich sein kцnnen.
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