NEOFOLLIN 5MG/ML INJ SOL 5X1ML (Estradiol)

Description and definition
The medicine contains estradiol valerate – a synthetically produced hormone identical to natural estrogen (female sex hormone).

Used:

as hormone replacement therapy (HRT) for:
lack of estrogen (hypoestrogenism), confirmed by a negative progesterone test and laboratory tests, endometrial atrophy and hypoestrogenic picture on vaginal cytology;
premature ovarian dysfunction in under 40 years of age (premature menopause);
general and local developmental disorders caused by hypoestrogenism (growth with insufficient activity of the genital organs (eunuchoid growth), delayed development of the genital organs (genital infantilism), incomplete development of the uterus (uterine hypoplasia)) ;
primary amenorrhea (absence of the 1st menstruation in girls under 16 years of age)
to stop dysfunctional uterine bleeding,
as a test for estrogen.
Use

Dosing and dosing regimens

Irregularities of the menstrual cycle in the first years after menarche
on the 4th, 11th and 18th days of the cycle, 2 ml (10 mg estradiol valerate), on the 18th day together with progesterone.

Replacement therapy for primary amenorrhea
2 ml (10 mg estradiol valerate), progesterone is added after 14 days.

Replacement therapy for Turner syndrome
2 ml (10 mg estradiol valerate) on days 1, 8 and 15 of the cycle, on days 15 and 22 combined with progesterone.
After the onset of bleeding: 2 ml ( 10 mg estradiol valerate) on days 4, 11 and 18 of the cycle; progesterone is added on days 18 and 25 of the cycle.

Replacement therapy for prolonged secondary amenorrhea in fertile age, a proven lack of endogenous estrogens and a positive estrogen test:
2 ml (10 mg estradiol valerate) on days 1, 8 and 15 of the cycle, added on days 15 and 22 progesterone. The dose is reduced in subsequent cycles after uterine bleeding is achieved. Usually it is enough to administer 2 ml of the drug on the 8th day of the cycle and again on the 15th day along with progesterone.
After the start of the menstrual cycle, a combined injection of 1-2 ml of the drug along with progesterone on the 18th day is sufficient.
/>After 3-6 cycles, progesterone alone is used on day 18.
If there is no bleeding, a progesterone test is performed to check endogenous estrogen production.